IGF-1 and insulin, together with TSH, have been reported to play a critical role in the regulation of thyroid follicular cell gene expression and proliferation [52, 58–61, 65, 73] raising the possibility that hypoinsulinemia in ubiquitous Glis3-deficient mice might influence the function and gene expression in thyroid follicular cells. Here, GLIS3 is linked to Hypoinsulinemia.