Biallelic loss-of-function mutations in human GLIS3 leads to a multi-organ phenotype that includes congenital hypothyroidism [16–24], while monoallelic, as well as biallelic, single nucleotide polymorphisms in GLIS3 are associated with an increased risk of thyroid dysfunction and CH [25–32]. This evidence concerns the gene GLIS3 and cyclic hematopoiesis.