These data indicate that GLIS3 does not play a major role in the regulation of thyroid follicular cell proliferation and suggest that the suppression of thyroid follicular cell proliferation in ubiquitous Glis3-deficient mice does not involve direct transcriptional regulation of cell cycle-related genes by GLIS3, but is related to abnormalities in other tissues, such as hypoinsulinemia that indirectly affect thyroid follicular cell proliferation. The gene discussed is GLIS3; the disease is Hypoinsulinemia.