CFC is characterized by dysmorphic craniofacial features, cardiac anomalies, neuromotor delay, cognitive impairment, ectodermal findings (xerosis cutis, sparse, curly and woolly or brittle hair, dystrophic nails), eye abnormalities (strabismus, nystagmus, and/or optic nerve hypoplasia) and hypotonia and is associated with alterations in BRAF, MAP2K1, MAP2K2, or KRAS genes [17]. The gene discussed is MAP2K2; the disease is Dry skin.