P2RY12 and respiratory system disorder: Importantly, considering that P2Y12R are present on glomus cells and have a fundamental role in chemoreflex activation already during moderate arterial pO2 reduction, which can be attributed to respiratory diseases, such as COPD [60]; antiplatelet medication may inadvertently influence peripheral chemoreflex sensitivity, consequently the clinical treatment benefit might be reduced for patients with chronic respiratory morbidities (Fig. 6).