Taken together, our findings show that our AD-like NHP model can be generated within a couple of months via a single AAV injection and recapitulates many defining pathological features of AD, including 3R/4R tau accumulation, tau hyperphosphorylation, tau propagation, NFT formation, neuronal loss, hippocampal atrophy, inflammatory responses, Aβ clearance deficit, vascular abnormalities, and multimodal cognitive dysfunctions. The gene discussed is MAPT; the disease is Alzheimer disease.