After 2–3 months of tau overexpression, 3R/4R tau aggregates, hyperphosphorylated tau, neurodegeneration, neuronal loss, hippocampal atrophy, neuroinflammation, vascular abnormalities, impaired Aβ clearance, spatial working memory and associative learning deficits were observed in these AD-like NHPs. Here, MAPT is linked to Alzheimer disease.