Together, our AD-like NHP model with 3R/4R tau aggregation, tau hyperphosphorylation, neuronal loss, hippocampal atrophy, neuroinflammation, Aβ clearance deficits, NFT formation, blood vessel damage and cognitive decline will serve as an effective tool for unveiling the pathogenic mechanisms of AD and developing disease-modifying treatments in the future. The gene discussed is MAPT; the disease is Mental deterioration.