The results of GO and KEGG pathway analyzed for these differentially expressed genes were presented in Fig. 7B. In the p53-mutant colon cancer cell, overexpressed MDM4 activated immune response-related functional pathways such as response to type I interferon, cytokine receptor binding, chemokine and NF-κB signaling pathway. The gene discussed is MDM4; the disease is malignant colon neoplasm.