MDM4 and cancer: Finally, MDM4 was identified as the prognostic factors for PFI in various cancer types: GBMLGG (HR = 1.416, p < 0.001), THYM (HR = 0.332, p < 0.028), READ (HR = 1.670, p < 0.042), PRAD (HR = 2.174, p < 0.001), PAAD (HR = 0.679, p = 0.032), LIHC (HR = 1.215, p = 0.049), KICH (HR = 4.615, p = 0.029), CESC (HR = 1.773, p = 0.004), LGG (HR = 1.518, p < 0.001), COADREAD (HR = 1.229, p = 0.042), and ACC (HR = 4.215, p < 0.001) (Fig. 3G–I).