Examples of other inorganic complexes that work as mitochondriotropics have been described [21, 62–64]; however, their anti-cancer activity is associated to mitochondrial-induced apoptosis, very different than that of Ru1, which at the concentrations used in this study do not induce apoptosis (Fig. 1H) or increase ROS (Fig. 8D). The gene discussed is SFMBT1; the disease is cancer.