In subgroup analysis, we observed a positive association between CRP and increased risk of kidney stones in the obese subgroup (p = 0.031), but this positive association did not meet statistical significance in overweight participants (p = 0.284), however, no correlation with the p for interaction that met statistical significance was observed, indicating that this correlation was not dependent on gender, BMI, smoking, alcohol consumption, hypertensio, diabetes and CKD, as all p for interaction > 0.05. This evidence concerns the gene CRP and nephrolithiasis.