In Model 2, we adjusted for age, gender and race, and the positive association between CRP and the risk of kidney stones persisted (OR = 1.09, 95% CI: 1.00–1.18, p = 0.03).The positive association between CRP and the risk of kidney stones still remained stable in the fully adjusted model (OR = 1.14, 95%CI: 1.02–1.26, p = 0.04). Here, CRP is linked to nephrolithiasis.