Tumour size (OR: 1.061; 95% CI: 1.020–1.104; p = 0.003), AFP level (OR: 2.008; 95% CI: 1.144–23.526; p = 0.015), tumour margin (OR: 2.645; 95% CI: 0.1211–5.775; p = 0.015), and APE (OR: 2.556; 95% CI: 1.085–6.021; p = 0.032) were independent predictors of MVI in multivariate analysis. This evidence concerns the gene AFP and neoplasm.