Binding of vosolide to NPR-B stimulates intracellular cyclic guanosine monophosphate (cGMP) production, which in turn inhibits the downstream signalling pathway of FGFR3 and promotes chondrocyte proliferation, differentiation and endochondral bone formation and has been proved to restore normal bone growth in a mouse model of ACH. This evidence concerns the gene FGFR3 and achondroplasia.