NFKB1 and osteosarcoma: Therefore, RARRES2 may maintain OSC stemness through the NF-kB signaling pathway.Similarly, shRARRES2 was transfected into OSCs, inject into the subcutaneous of nude mice for four weeks, the tumorigenic capacity of osteosarcoma cells was significantly suppressed, leading to a significant reduction in tumor volume and weight (Fig. 10H).