Invasive rates of FAK inhibitors in ESCC cells/CAFs #5 coculture system were significantly lower than those in KYSE410 or KYSE510 cells/CAFs #1 to #4 coculture system, indicating that CAFs #5 could not induce the anti-invasive resistance of FAK inhibitors in ESCC treatment. The gene discussed is PTK2; the disease is esophageal squamous cell carcinoma.