Several metabolic pathways, such as protein digestion and absorption (KEGG ID: hsa04974), choline metabolism in cancer (KEGG ID: hsa05231), central carbon metabolism in cancer (KEGG ID: hsa05230), glutathione metabolism (KEGG ID: hsa00480), ABC transporters (KEGG ID: hsa02010), or glycerophospholipid metabolism (KEGG ID: hsa00564), have been enriched upon defactinib treatment (Fig. 2a, b). The gene discussed is ABCG2; the disease is cancer.