We also found that AKT2S128/CCTαS315/319/323-positive CAFs subset provides the adequate supply of PCs for the persistent activation of intratumoral STAT3 maintained by the Tyk2/JAK2 complex, and resultantly induced FAK-targeted therapy resistance and the ESCC malignancy. This evidence concerns the gene TYK2 and esophageal squamous cell carcinoma.