AKT2 and esophageal squamous cell carcinoma: We examined the physical association between AKT2 and CCTα using immunoprecipitation assays, and found that defactinib (10 μM) facilitated the formation of AKT2/CCTα complex, and the phosphorylation of CCTα Ser315/319/323 in AKT2/CCTα complex in CAFs #1 alone or cocultured with indicated ESCC cells (Fig. 4f).