As the results in Fig. 6e, f, and Supplementary Fig. 14a–c shown, ADORA1 depletion effectively disrupted the interaction between Tyk2 and JAK2, and inhibited the phosphorylation of JAK2 in Tyk2/JAK2 complex and the activation of STAT3 in indicated ESCC cells incubated with PC (16:0/20:4) or glycerophosphocholine. Here, STAT3 is linked to esophageal squamous cell carcinoma.