HIF1A and neoplasm: It not only promotes tumor resistance to multiple therapies (PDT, SDT, RT, etc.)by seriously limiting their critical ROS generation, but also dramatically activates the expression of HIF-1α which influences multiple pivotal steps within the metastatic cascade, such as epithelial-mesenchymal transition, invasion and establishment of the premetastatic niche at the distant site and so on26–29.