As shown in Supplementary Fig. 31, the highest percents of F4/80+ and CD3+CD8+ cells were detected in mice treated with HIL@Z/P/H+Red+NIR, providing the evidence that the changes in the tumor microenvironment, including nitrosative stress-triggered cell death and hypoxia alleviation promoted the infiltration of macrophages and cytotoxic T cells. This evidence concerns the gene CD8A and neoplasm.