Among hematological malignancies, we showed that Acute Promyelocytic Leukemia (APL), a subtype of Acute Myeloid Leukemia (AML), almost invariably characterized by t (15;17) translocations coding for the PML/RARa fusion protein, is strongly negatively-affected by an elevated body mass index18,19. This evidence concerns the gene RARA and acute promyelocytic leukemia.