C3 and metabolic dysfunction-associated steatohepatitis: GO enrichment analysis of DEGs between C3 and C0 or C3 and C1/2 showed that C3 upregulated pathways of antigen processing and presentation, monocyte chemotaxis, chemokine-mediated signaling, and down-regulated pathways of the immune response, glycolysis, phagocytosis (Fig. 7d, e), as observed in advanced NASH and cirrhosis12,13.