Finally, our scRNAseq analysis shows the presence of DAMs in the liver of NAFLD patients, which share the same phenotype, including expression of TREM2, CD9, GPNMB, MHCII (HLA-DRB1), C1QA, and CLEC10A, as those found in the livers of patients with NASH and cirrhosis. Here, TREM2 is linked to metabolic dysfunction-associated steatotic liver disease.