AFF2 and epilepsy: This could certainly contribute to the epilepsy and ASD/ID experienced by patients, as glutamatergic neuron network activity is impaired in many human iPSC-derived models of epilepsy and ASD including KCNQ2, MECP2, FMR1, KCNT1, ATRX, AFF2, SCN2A, ASTN2, CNTN5, EHMT2, and idiopathic cases50–61.