INS and Impaired glucose tolerance: In the absence of evidence of a difference in tissue masses (Suppl. Fig. 2), hepatic (Figure 1E–H) or renal (Figure 2E) glucose handling, systemic or hepatic insulin resistance (Figure 1B, E–H) or renal inflammation or fibrosis (Figure 2A–C), we considered alternate hypotheses to explain the impaired glucose tolerance observed in 16- to 18-week-old male RT-SAKO mice.