To address this, a technique to enrich populations on the basis of an intracellular marker and potential to monitor MRD was developed using a common B-cell lymphoma , follicular lymphoma (FL), characterized by the high intracellular B-cell lymphoma 2 (BCL2) (an anti-apoptosis regulator) expression as an exemplar disease model. The gene discussed is BCL2; the disease is B-cell non-Hodgkin lymphoma.