TCF4 and neoplasm: Finally, β-catenin/Tcf4 induces Zinc finger E-box binding homeobox1 (ZEB1), a known mediator of EMT [79], and that EMT induction is linked positively with PD-L1 expression on tumor cells, as evidenced by the implication of the EMT activator ZEB1 in relieving miR-200-mediated repression of PD-L1 activity on tumor cells [80].