The ligand-receptors interactions revealed that the interactions between tumor cells and T cells were mainly focused on the interactions between MHC molecules on tumor cells and CD8 molecules on T cells (such as H2d1-Cd8a, H2d1-Cd8b1, H2k1-Cd8a, H2k1-Cd8b1), which is known as the classical antigen presentation pathway [19]. This evidence concerns the gene HLA-C and neoplasm.