To understand whether THP1 or human monocytes can affect tumor cell resistance, same as shown for A549 cells, we first detected apoptosis in HCCs cells treated with etoposide with aid of Annexin V. HCCs cells were first incubated with monocytes in ratio 50:1 for 20 h and then 30 μM etoposide was administrated for next 24 h. The gene discussed is ANXA5; the disease is neoplasm.