In the present study, we have had the opportunity to conduct a direct head-to-head comparison of the autoradiographic binding properties [18F]-Flortaucipir, [18F]-MK-6240 and [18F]-PI-2620 in the same postmortem brain tissue material from AD, non-AD tauopathies [Pick’s disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), chronic traumatic encephalopathy (CTE)], cerebral amyloid angiopathy (CAA), synucleinopathies (dementia with Lewy bodies (DLB)), transactive response DNA-binding protein 43 (TDP-43)-frontotemporal lobe degeneration (FTLD) and control cases. Here, TARDBP is linked to cerebral amyloid angiopathy.