We conducted a review of the medical literature for every published case of APDS with documented age at last report and a molecular diagnosis in PIK3CD or PIK3R1. We identified 256 individuals who had a molecular diagnosis for APDS as well as age at last report; 193 individuals with APDS1 and 63 with APDS2. The gene discussed is PIK3R1; the disease is activated PI3K-delta syndrome.