Considering that this different proportion of CD4+ T cells might ultimately determine the ability of CIKs to kill tumor cells, they investigated how the CD4+ T subset induced phosphorylation of the AKT pathway by secretion of IL17A and upregulated the expression of T-bet/Eomes transcription factors, thereby restoring the function of CD8+/CD3+CD56+T cells and reversing the depletion of PD-1+Tim-3+T cells [8]. Here, CD4 is linked to neoplasm.