As is the case for MR antagonists [48], beneficial effects of H2 antagonism might not depend only on blood pressure reduction but could also rely on local effects, e.g., improvements of heart morphology [31, 37] and while cardiac fibrosis was not examined in the present study, we found no effect of ranitidine on heart weight which agrees with neutral effect on hypertension. The gene discussed is NR3C2; the disease is hypertensive disorder.