NR3C2 and Hypertension: As is the case for MR antagonists [48], beneficial effects of H2 antagonism might not depend only on blood pressure reduction but could also rely on local effects, e.g., improvements of heart morphology [31, 37] and while cardiac fibrosis was not examined in the present study, we found no effect of ranitidine on heart weight which agrees with neutral effect on hypertension.