GO analysis revealed that these genes play roles in vital functions, such as cellular protein modification process including N‐glycan fucosylation (FUT8), mucin type O‐glycan biosynthesis (GALNT10 and GALNT18), negative regulation of cell cycle process (CENPF, TFDP2, CNOT2, PTEN) and so on, thus confirming HPV breakpoints are associated with cancers and may serve as regulators of oncogene expression and drivers of tumourigenesis (Figure S8B). This evidence concerns the gene CENPF and cancer.