The lactobacillus Plantarum, a probiotic found in the mouth and gut, and inulin supplements, fermentable non-digestible dietary fibers that can improve metabolic function by intestinal microbiota modulation, or their combination, reduced oxidative stress and anxiety-like behavior and increased BDNF and serotonin levels in the amygdala highlighting the importance of the gut-brain axis, and in particular the gut-amygdala axis, in the psychiatric consequences of T2D [104, 105]. This evidence concerns the gene BDNF and type 2 diabetes mellitus.