Oxidative stress, high levels of cytokines (TNF-α, IL-1β, IL-6, IL-10), and dysregulation of the proliferation and differentiation of oligodendrocytes and astrocytes were observed in the prefrontal cortex and hippocampus of T1D mice exhibiting concomitantly anxiety-like behavior [93]. This evidence concerns the gene IL6 and type 1 diabetes mellitus.