This could be ascribed to the effect of D‐Gel, since inflammation alleviation in tumor microenvironment has been reported to deplete Tregs.[24] Consequently, with the concomitant increase in tumor‐infiltrating CD8+ T cells and decrease in Tregs, ZCVCT26@D‐Gel substantially elevated CD8+ T cells to Tregs ratio, leading to significant expansion of tumor cell‐reactive T cells (IFN‐γ+CD8+), suggesting an enhanced antitumor immune response. Here, CD8A is linked to neoplasm.