Specifically, we found that 10-week-old Apoe-/- mice presented with atherosclerotic plaques at the level of the aortic valve that exhibited histopathological characteristics such as moderate macrophage presence, intracellular lipid accumulation, and foam cell formation similar to those described for fatty streaks or type II atherosclerotic lesions in humans according to the American Heart Association histological classification of atherosclerosis [45]. Here, APOE is linked to atherosclerosis.