This was detected in only 10% of the population of 26-week-old Apoe-/- mice, suggesting that only a limited minority of lesions were of the Vβ type [44], while 40% of the population of 52-week-old Apoe-/- mice presented with aortic valve calcification, indicating that a considerable proportion of lesions were of the Vβ type [44]. The gene discussed is APOE; the disease is aortic valve calcification.