The present study additionally demonstrated that in Apoe-/- mice, the progression of atherosclerosis towards late disease stages is coincident with the ubiquitous development of extensive atherosclerotic lesions in all three left coronary artery major branches (LADCA, CIRCUMFLEX, and LMCA) and that the ensuing partial occlusion of the lumen of coronary arteries by atherosclerotic plaques is a histopathological characteristic of late disease stages but not intermediate or early stages. Here, APOE is linked to atherosclerosis.