NFE2L2 and malignant colon neoplasm: Luteolin, a dietary flavone molecule, modulates various signaling pathways involved in carcinogenesis and has apoptotic effects mediated by the DNA demethylation of the nuclear factor erythroid 2-related factor 2 (NRF2) promoter and the interaction of Nrf2 and p53 in human colon cancer cells [104].