Resveratrol, a chemical mostly found in red grapes, alters the methylation of histones in the TP53 promoter in human breast cancer cells and upregulates the expression of SET domain-containing lysine methyltransferase 7/9 (SET7/9) in colorectal cells to positively regulates p53 through its mono-methylation function [102,103]. The gene discussed is SETD7; the disease is breast carcinoma.