TRAIL binds to TRAIL death receptors, DR4 and DR5, on tumor cells, leading to tumor cell apoptosis, but does not induce apoptosis in normal cells because they express TRAIL decoy receptors, DcR1, DcR2, and osteoprotegerin (OPG) [41,42,43]. The gene discussed is TNFRSF11B; the disease is neoplasm.