This analysis, performed as fold change (Leiomyoma/paired Myometrium), resulted in the identification of 3443 lncRNAs with altered expression, of which, the expression of 870 lncRNAs was increased, while the expression of 746 lncRNAs was decreased by 1.5-fold or greater in MED12-mutated specimens as compared with non-mutated specimens. The gene discussed is MED12; the disease is leiomyoma.