The analysis showed the involvement of many proteins such as MAP3K7, RPS6KB1, PPP2R2A, RPS6KB2, and HK2 in this interactive network, all of which are well established in leiomyoma pathogenesis [39,40,41,42,43], and other proteins such as ULK1, ELAVL1, SHC3, INSR, and IRS2, which are novel and require further investigation. This evidence concerns the gene IRS2 and leiomyoma.