The treatment of KK-Ay mice with an AT2R antagonist (PD123319) did not have significant effects on insulin sensitivity in this study [109]; however, positive effects on metabolism by means of AT2R were found in another study on KK-AY mice, in which the intraperitoneal injections of AT2R agonist (compound 21, C21) reduced insulin resistance [110]. Here, INS is linked to Insulin resistance.