For instance, it was shown that in healthy awake swine, the separate blockade of AT1R and ETA/ETB receptors produced similar vasodilatory responses as the combined blockade of these receptors [48]; however, 2–3 weeks after the myocardial infarction, the coronary vasodilatory responses to individual blockades of AT1R and ETA/ETB receptors were abolished in spite of that fact that the expression of AT1R and ETA receptors was not altered. This evidence concerns the gene EDNRA and myocardial infarction.