Subsequent studies showed that blockade of AT1R by losartan in rats with the myocardial infarction improved cardiac performance and reversed several negative biochemical processes, such as elevated sarcoplasmic reticulum Ca2+ uptake, the activation of Ca2+ pump protein, and phospholamban protein, as well as the stimulation of myofibrils (MF) Ca2+-activated ATPase, myosin heavy chain (α-MHC) mRNA, and β-MHC mRNA [73]. This evidence concerns the gene AGTR1 and myocardial infarction.