In mice studies, IL-1β may be a potential inducer of Helicobacter hepaticus-mediated colitis by stimulating innate lymphoid cells and conscription of neutrophils via the IL-1 receptor signaling pathway [71], which modulates mucosal aggregation of T cells and produces TH17, resulting in colitis [72,73] and further carcinogenesis [74]. The gene discussed is IL1B; the disease is colitis.