UCHL1 and Cognitive impairment: The nitrosylated UCHL1 may be involved in the noncanonical transnitrosylation network, which transfers NO from UCHL1 to cyclin-dependent kinase 5 and then to dynamin-related protein 1; realization of such a scenario may cause serious consequences, including mitochondrial fragmentation and consequent synapse loss and cognitive impairments [133].