ABCB1 and Alzheimer disease: Building upon the findings that H. perforatum extracts with low hyperforin content show bioactivity in AD mouse models, leading to a reduction of Aβ in brain tissue, and demonstrate a hyperforin-independent activation of ABCB1 and ABCC1 transporters [17]—already identified as potential treatment targets for AD [5,14,15,19,22]—other studies have broadened this perspective.