In addition, the clinicopathological parameters also demonstrated that the expression of exosomal miR-92b-5p was significantly correlated with stage (p = 0.033), estrogen receptor (ER) status (p = 0.047), progesterone receptor (PR) status (p = 0.007), and epidermal growth factor receptor 2 (HER-2) status (p = 0.038) (Table 2), indicating that exosomal miR-92b-5p could be considered a non-invasive body fluid biomarker for breast cancer detection. This evidence concerns the gene ESR1 and breast cancer.