It has been shown that in the CA1 and CA3 regions of the hippocampus, as well as in the temporal cortex, genes associated with Alzheimer’s disease, such as these encoding α-secretase, amyloid precursor protein, β-secretase, presenilin 1 and 2, and tau protein are dysregulated as a result of ischemia caused by cardiac arrest (Table 1) [82]. Here, APP is linked to cardiac arrest.