Administration of CHIR99021 at 18 h post-LPS injection, after the subsiding of the immune response, also revealed no alterations in the recruitment of leukocytes, neutrophils, eosinophils, Ly-6C+ monocytes, alveolar macrophages, interstitial macrophages, T cells, and CD4+ T cells at 30 h and 72 h post-LPS-induced ALI (Figure 3a). The gene discussed is CD4; the disease is acute respiratory distress syndrome.