Using the Ishikawa endometrial cancer cell line transfected with either control siRNA or EphA2 siRNA, we performed a high-throughput drug screen using two drug libraries (the Broad Collection-Informer Set and Selleck Bioactives Collection) containing a total of 1510 drugs comprising FDA-approved agents, investigational agents, and bioactive molecules. Here, EPHA2 is linked to endometrial cancer.