ACTC1 and cardiomyopathy: The data obtained from the comparisons between the specific mutated genes showed variable results; for instance: the comparison between MYBPC3 and MYH7 did not reveal significant differences in cardiomyopathy phenotypical expression [107,108]; the comparison between the genes encoding the sarcomere thin filament (TNN2, TNNT3, TMP1 and ACTC) and the thick filament (MYBPC3, MYH7 and MYL2) concluded that there was an increased risk of advanced LV dysfunction and heart failure in cases with thin filament mutations, and an equal arrhythmic risk [109].