Indeed, apart from the reported mTOR dysregulation in models of cognitive decline [24], evidence in favor of the role of mTOR as an inhibitor of autophagy, and in the decrease of the clearance of Aβ and of NFTs was provided by the use of rapamycin, vinblastine, metformin, temsirolimus, carbamazepine, and dactosilib in transgenic AD murine models [25,26,27,28,29,30,31,32,33]. This evidence concerns the gene MTOR and Mental deterioration.