In addition to blocking the immune-suppressive effect of vascular epidermal growth factors (VEGFs), multi-TKIs seem to have a favorable immune modulating effect by decreasing the arrival of myeloid-derived suppressor cells and tumor-associated macrophages and increasing the infiltration of dendritic cells, natural killer cells and CD8+ lymphocytes, potentially making the combination of multi-TKIs with ICIs reasonable [69]. Here, CD8A is linked to neoplasm.