VEGFA and neoplasm: The components of the TME are tumor-associated macrophages (TAMs); pro-inflammatory cytokines; other immune checkpoint modulators; regulatory T-cells (Treg); immunosuppressive cytokines such as transforming growth factor-beta (TGF-beta); pro-angiogenic cytokines like fibroblast growth factor (FBGF); or vascular endothelial growth factor (VEGF).