RPE65 and severe early-childhood-onset retinal dystrophy: There is overlap in the genes that cause LCA and EOSRD, but some patterns exist: the GUCY2D, NMNAT1, CEP290, and AIPL1 genes are more likely to cause LCA, whereas RPE65, LRAT, and RDH12 are more commonly associated with the EOSRD phenotype [5].