We demonstrated how cfChIP-seq on NSCLC patients resulted in the enrichment of genes known to be upregulated in NSCLC, such as EGFR and RIN3, whereas SCLC patients had increased gene enrichment of, e.g., KIF19 and SMAD4, which are upregulated in SCLC tumors. This evidence concerns the gene RIN3 and non-small cell lung carcinoma.