We demonstrated how cfChIP-seq on NSCLC patients resulted in the enrichment of genes known to be upregulated in NSCLC, such as EGFR and RIN3, whereas SCLC patients had increased gene enrichment of, e.g., KIF19 and SMAD4, which are upregulated in SCLC tumors. The gene discussed is SMAD4; the disease is small cell lung carcinoma.