NEFL and Alzheimer disease: In comparing proteomic panels to conventional AD blood biomarkers (Aβ, p-tau181 and NfL), a 19-protein panel is more accurate in diagnosing AD compared to cognitively unimpaired individuals (AUC = 0.98 for protein panel and 0.87 for traditional blood biomarkers, p < 0.001) in Hong Kong Chinese individuals [203].