Similarly, the prediction accuracy of the underlying cause of cognitive impairment in individuals from specialized memory clinics followed over a 4-year period was higher with a diagnostic model combining p-tau217 or p-tau181 with cognitive tests and APOE status (AUC 0.90 [0.86–0.94]), compared to predictions made by memory clinic specialists (AUC 0.72 [0.65–0.78], p < 0.001) [210]. Here, APOE is linked to Cognitive impairment.