Sucrose-fed rats also evinced hypertriglyceridemia, enhanced liver lipogenic gene expression and carbohydrate dysmetabolism (increased glucokinase, fructokinase, and higher glycogen content), down regulation of the antioxidant defense system (decreased GSH levels together with reduced GR expression), and an inflammatory state (high COX-2 and iNOS protein content) and altered insulin pathway response. The gene discussed is PTGS2; the disease is hypertriglyceridemia.