In addition, a study using an AQP9 inhibitor in a mouse cecal ligation puncture (CLP)-model for sepsis indicated that administration AQP9 inhibitor attenuates the cardiac and renal dysfunction caused by sepsis, reduces the activation of the NLR family pyrin domain containing the 3 (NLRP3)-inflammasome pathway and myeloperoxidase (MPO) activity in lung tissue [27]. The gene discussed is NLRP3; the disease is Sepsis.