In this study, C57BL/6J mice were fed a high-fat diet (HFD) and given an oral gavage of 20 mg/kg SRP daily for 11 weeks to explore the mechanisms of SRP on resistance to HFD-induced obesity, specifically via Src-PI3K/Akt signaling. Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.