RGD-BBN heterodimers were labeled with three positron-emitting radionuclides, namely 18F, 64Cu, and 68Ga, and the PET studies with these three radiotracers were conducted in T-47D (GRPR+/low integrin αvβ3) and MDA-MB-435 (GRPR−/integrin αvβ3+) BC models. Here, GRPR is linked to breast cancer.