The comparative analysis identified four platelet proteins, namely Ras-related protein Rab-7a (Rab-7a), Ran-specific binding protein 1 (RANBP1), Rho GDP-dissociation inhibitor 1 (RhoGDI1), and 14–3-3 gamma with progressively decreased protein expression in patients with liver cirrhosis. Here, ARHGDIA is linked to cirrhosis of liver.